Sustained reprogramming of the estrogen response after chronic exposure to endocrine disruptors.

ABSTRACT: The pervasive nature of estrogenic industrial and dietary compounds is a growing health concern linked to cancer, obesity, and neurological disorders. Prior analyses of endocrine disruptor action have focused primarily on the short-term consequences of exposure. However, these studies are unlikely to reflect the consequences of constant exposures common to industrialized countries. Here we examined the global effects of long-term endocrine disruption on gene transcription and estrogen signaling. Estrogen-dependent breast cancer cell lines were chronically treated with physiologically relevant levels of bisphenol A or genistein for more than 70 passages. Microarray analysis demonstrated global reprogramming of the transcriptome when compared with a similarly cultured control cell line. Estr

SUBMITTER: Patterson AR 

PROVIDER: S-EPMC4347288 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature