Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension.

ABSTRACT:

Rationale

Pulmonary arterial hypertension (PAH) is a medically incurable disease resulting in death from right ventricular (RV) failure. Both pulmonary vascular and RV remodeling are linked to dynamic changes in the microvasculature. Therefore, we hypothesized that circulating angiostatic factors could be linked to outcomes and represent novel biomarkers of disease severity in PAH.

Objectives

We sought to determine the relationship of a potent angiostatic factor, endostatin (ES), with disease severity and mortality in PAH. Furthermore, we assessed genetic predictors of ES expression and/or function and their association with outcomes in PAH.

Methods

We measured levels of serum ES in two independent cohorts of patients with PAH. Contemporaneous clinical data included N

SUBMITTER: Damico R 

PROVIDER: S-EPMC4347439 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature