Low-dose hydrocortisone reduces norepinephrine duration in severe burn patients: a randomized clinical trial.

ABSTRACT:

Introduction

The aim of this study was to assess the effect of low-dose corticosteroid therapy in reducing shock duration after severe burn.

Methods

A placebo-controlled, double-blind, randomized clinical trial (RCT) was performed on two parallel groups in the burn intensive care unit (ICU). Patients were randomized to receive either low-dose corticosteroid therapy or placebo for seven days. A corticotropin test was performed at the time of randomization, before the administration of the treatment dose. Thirty-two severely burned patients with refractory shock (>0.5 μg/kg/min of norepinephrine) were prospectively included in the study.

Results

We included 12 patients in the hydrocortisone-treated group and 15 patients in the placebo group in the final analysis. Among

SUBMITTER: Venet F 

PROVIDER: S-EPMC4347659 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature