The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity.

ABSTRACT:

Background

Asthma is a common chronic disease worldwide and Ascaris lumbricoides infection (ascariasis) is frequent in tropical regions. However, the effect of ascariasis on asthma severity has not been sufficiently explored. We sought to evaluate the influence of the IgE immune response to Ascaris extract and purified house dust mites (HDM) and Ascaris allergens on indicators of asthma severity in patients living in the tropics.

Methods

Asthmatic patients from Cartagena, Colombia were recruited. Clinical assessment included questionnaires, physical examination, allergy skin tests, spirometry, parasite stool examination and IgE antibody measurements. Asthma was diagnosed by a physician according to validated criteria. Indicators of severity were occurrence of severe dyspnea

SUBMITTER: Buendia E 

PROVIDER: S-EPMC4347909 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature