Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity.

ABSTRACT: Epigenetics is currently one of the hottest topics in basic and biomedical research. However, to date, most of the studies have been descriptive in nature, designed to investigate static distribution of various epigenetic modifications in cells. Even though tremendous amount of information has been collected, we are still far from the complete understanding of epigenetic processes, their dynamics or even their direct effects on local chromatin and we still do not comprehend whether these epigenetic states are the cause or the consequence of the transcriptional profile of the cell. In this review, we try to define the concept of synthetic epigenetics and outline the available genome targeting technologies, which are used for locus-specific editing of epigenetic signals. We report early succ

SUBMITTER: Jurkowski TP 

PROVIDER: S-EPMC4347971 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature