Rph1/KDM4 mediates nutrient-limitation signaling that leads to the transcriptional induction of autophagy.

ABSTRACT:

Background

Autophagy is a conserved process mediating vacuolar degradation and recycling. Autophagy is highly upregulated upon various stresses and is essential for cell survival in deleterious conditions. Autophagy defects are associated with severe pathologies, whereas unchecked autophagy activity causes cell death. Therefore, to support proper cellular homeostasis, the induction and amplitude of autophagy activity have to be finely regulated. Transcriptional control is a critical, yet largely unexplored, aspect of autophagy regulation. In particular, little is known about the signaling pathways modulating the expression of autophagy-related genes, and only a few transcriptional regulators have been identified as contributing in the control of this process.

Results

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SUBMITTER: Bernard A 

PROVIDER: S-EPMC4348152 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature