Novel serum biomarkers for detection of excessive alcohol use.

ABSTRACT:

Background

Construct interview that correctly identifies those with alcohol use disorder have limitation, especially when the subjects are motivated to minimize the magnitude of drinking behavior. Current laboratory tests to detect excessive alcohol consumption are limited by marginal sensitivity/specificity. Excessive drinking has been shown to affect several organ systems, which may be reflected in changes in quantity of plasma proteins. Our aim was to employ novel proteomic analyses to identify potential markers for excessive alcohol use.

Methods

A prospective case-control study included 49 controls and 54 excessive drinkers (discovery cohort). The serum proteomic analyses in these subjects were performed, and the results were tested in the verification cohort (40 control

SUBMITTER: Liangpunsakul S 

PROVIDER: S-EPMC4348329 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature