The pharmacogenetics of alcohol use disorder.

ABSTRACT:

Background

Annually, the use and abuse of alcohol contributes to millions of deaths and billions of dollars in societal costs. To determine the impact of genetic variation on the susceptibility to the disorder and its response to treatment, studies have been conducted to assess the contribution of a variety of candidate genetic variants. These variants, which we review here, were chosen based upon their observed or hypothesized functional relevance to alcohol use disorder (AUD) risk or to the mechanism by which medications used to treat the disorder exert their effects.

Methods

This qualitative review examines studies in which candidate polymorphisms were tested as moderator variables to identify pharmacogenetic effects on either the subjective response to alcohol or the out

SUBMITTER: Jones JD 

PROVIDER: S-EPMC4348335 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature