Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma.

ABSTRACT:

Background

Lung cancer is one of the leading causes of cancer-related death. At the time of diagnosis, more than half of the patients will have disseminated disease and, yet, diagnosing can be challenging. New methods are desired to improve the diagnostic work-up. Exosomes are cell-derived vesicles displaying various proteins on their membrane surfaces. In addition, they are readily available in blood samples where they constitute potential biomarkers of human diseases, such as cancer. Here, we examine the potential of distinguishing non-small cell lung carcinoma (NSCLC) patients from control subjects based on the differential display of exosomal protein markers.

Methods

Plasma was isolated from 109 NSCLC patients with advanced stage (IIIa-IV) disease and 110 matched control

SUBMITTER: Jakobsen KR 

PROVIDER: S-EPMC4348413 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature