Estimating the life course of influenza A(H3N2) antibody responses from cross-sectional data.

ABSTRACT: The immunity of a host population against specific influenza A strains can influence a number of important biological processes, from the emergence of new virus strains to the effectiveness of vaccination programmes. However, the development of an individual's long-lived antibody response to influenza A over the course of a lifetime remains poorly understood. Accurately describing this immunological process requires a fundamental understanding of how the mechanisms of boosting and cross-reactivity respond to repeated infections. Establishing the contribution of such mechanisms to antibody titres remains challenging because the aggregate effect of immune responses over a lifetime are rarely observed directly. To uncover the aggregate effect of multiple influenza infections, we developed a m

SUBMITTER: Kucharski AJ 

PROVIDER: S-EPMC4348415 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature