Association between IL-6-174G/C polymorphism and the risk of sepsis and mortality: a systematic review and meta-analysis.

ABSTRACT:

Background

Recent studies have reported the association between IL-6-174G/C polymorphism and sepsis. However, the results are inconclusive and conflicting. To better understand the role of IL-6-174G/C polymorphism in sepsis, we conducted a comprehensive meta-analysis.

Methodology

Literature search was conducted through PubMed, Embase, Web of Knowledge databases until July 29, 2013. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed- or random-effect model based on heterogeneity test in total and subgroup analyses.

Results

Twenty studies on the risk of sepsis and seven studies on sepsis mortality were included. None of the results showed evidence of a significant association between IL-6-174G/C polymorphism and sepsis risk in ov

SUBMITTER: Gao JW 

PROVIDER: S-EPMC4348480 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature