Microarray-based characterization of differential gene expression during vocal fold wound healing in rats.

ABSTRACT: The vocal fold (VF) mucosa confers elegant biomechanical function for voice production but is susceptible to scar formation following injury. Current understanding of VF wound healing is hindered by a paucity of data and is therefore often generalized from research conducted in skin and other mucosal systems. Here, using a previously validated rat injury model, expression microarray technology and an empirical Bayes analysis approach, we generated a VF-specific transcriptome dataset to better capture the system-level complexity of wound healing in this specialized tissue. We measured differential gene expression at 3, 14 and 60 days post-injury compared to experimentally naïve controls, pursued functional enrichment analyses to refine and add greater biological definition to the previously

SUBMITTER: Welham NV 

PROVIDER: S-EPMC4348567 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature