Number and frequency of albuminuria measurements in clinical trials in diabetic nephropathy.

ABSTRACT:

Background and objectives

Albuminuria change is often used to assess drug efficacy in intervention trials in nephrology. The change is often calculated using a variable number of urine samples collected at baseline and end of treatment. Yet more albuminuria measurements usually occur. Because albuminuria shows a large day-to-day variability, this study assessed to what extent the average and the precision of the antialbuminuric drug effect varies with the number of urine collections at each visit and the number of follow-up visits.

Design, setting, participants, & measurements

This study used data from three randomized intervention trials (Aliskiren Combined with Losartan in Type 2 Diabetes and Nephropathy, Selective Vitamin D Receptor Activation for Albuminuria Lowering, an

SUBMITTER: Kropelin TF 

PROVIDER: S-EPMC4348688 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature