Dataset Information

Association of SNPs in GHSR rs292216 and rs509035 on dietary intake in Indonesian obese female adolescents.

ABSTRACT:

Background

Obesity has been linked to high dietary intake and low physical activity. Studies showed that those factors were not only regulated by environment but also by genetic. However, the relationship is less been understood in obese children and adolescents.

Objective

The objective of this study was to examine the role of SNPs in GHSR rs292216 and rs509035 on dietary intake in obese female adolescents.

Methods

This is an observational study with cross sectional design. Respondents were obese female adolescents enrolled from obesity screening done in six junior high schools in Yogyakarta. Dietary intake was measured using 6 days 24 hours inconsecutive dietary recall. Genotyping of 2 SNPs from GHSR was done using FRLP-PCR.

Results

There were 78 obese female adolescents joined this study. We found that no significant association between SNPs GHSR and dietary intake (p < 0.05). In addition, a SNP-SNP interaction analysis shown there is no difference between combination of GHSR rs292216 and rs509035 on dietary intake (p < 0.05).

Conclusion

We concluded that SNPs on GHSR rs292216 and rs509035 were not related to dietary intake in Indonesian obese female adolescents. Further study is necessary to investigate the effect of those genes on dietary intake in the broader population.

SUBMITTER: Luglio HF

PROVIDER: S-EPMC4348703 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Association of SNPs in GHSR rs292216 and rs509035 on dietary intake in Indonesian obese female adolescents.

Luglio Harry Freitag HF Inggriyani Cut Gina CG Huriyati Emy E Julia Madarina M Susilowati Rina R

International journal of molecular epidemiology and genetics 20141215 4

<h4>Background</h4>Obesity has been linked to high dietary intake and low physical activity. Studies showed that those factors were not only regulated by environment but also by genetic. However, the relationship is less been understood in obese children and adolescents.<h4>Objective</h4>The objective of this study was to examine the role of SNPs in GHSR rs292216 and rs509035 on dietary intake in obese female adolescents.<h4>Methods</h4>This is an observational study with cross sectional design. ...[more]

PMID: 25755847

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Dataset Information

Association of SNPs in GHSR rs292216 and rs509035 on dietary intake in Indonesian obese female adolescents.

Background

Objective

Methods

Results

Conclusion

Publications

Association of SNPs in GHSR rs292216 and rs509035 on dietary intake in Indonesian obese female adolescents.

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