Urinary phthalate metabolites and biomarkers of oxidative stress in pregnant women: a repeated measures analysis.

ABSTRACT:

Background

Phthalate exposure occurs readily in the environment and has been associated with an array of health end points, including adverse birth outcomes. Some of these may be mediated by oxidative stress, a proposed mechanism for phthalate action.

Objectives

In the present study, we explored the associations between phthalate metabolites and biomarkers of oxidative stress measured in urine samples from multiple time points during pregnancy.

Methods

Women were participants in a nested case-control study of preterm birth (n = 130 cases, n = 352 controls). Each was recruited early in pregnancy and followed until delivery, providing urine samples at up to four visits. Nine phthalate metabolites were measured to assess exposure, and 8-hydroxydeoxyguanosine and 8-isopro

SUBMITTER: Ferguson KK 

PROVIDER: S-EPMC4348741 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature