The FlyCatwalk: a high-throughput feature-based sorting system for artificial selection in Drosophila.

ABSTRACT: Experimental evolution is a powerful tool for investigating complex traits. Artificial selection can be applied for a specific trait and the resulting phenotypically divergent populations pool-sequenced to identify alleles that occur at substantially different frequencies in the extreme populations. To maximize the proportion of loci that are causal to the phenotype among all enriched loci, population size and number of replicates need to be high. These requirements have, in fact, limited evolution studies in higher organisms, where the time investment required for phenotyping is often prohibitive for large-scale studies. Animal size is a highly multigenic trait that remains poorly understood, and an experimental evolution approach may thus aid in gaining new insights into the genetic basi

SUBMITTER: Medici V 

PROVIDER: S-EPMC4349086 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature