IL28B gene polymorphisms in mono- and HIV-coinfected chronic hepatitis C patients.

ABSTRACT:

Introduction

Single-nucleotide polymorphisms (SNPs) associated with hepatitis C virus (HCV) clearance were identified near the IL28B gene. Coinfection by the human immunodeficiency virus (HIV) influences the course of HCV contributing to liver damage. Nevertheless, little is known about the relationship between these SNPs and HCV/HIV coinfection. Our aim was to estimate the frequencies of the allelic and genotypic variants of the IL28B polymorphisms rs12979860 (C/T) and rs8099917 (T/G) and their possible association with the establishment of HCV infection.

Methodology

A total of 199 non-infected controls and 230 patients with chronic hepatitis C, including 53 coinfected with HIV, participated in the study. Genotyping consisted of polymerase chain reaction and subsequent anal

SUBMITTER: Bertol BC 

PROVIDER: S-EPMC4349181 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature