Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder.

ABSTRACT: Episodic angioedema with eosinophilia (Gleich syndrome) is a rare disorder characterized by episodes of angioedema and eosinophilia that occur at monthly intervals and resolve spontaneously without therapy. Despite the striking periodicity of this disorder, its similarity to other cyclic hematopoietic disorders with multilineage involvement has not been assessed. To characterize the involvement of cell lineages in the etiology and pathogenesis of episodic angioedema with eosinophilia, four subjects were evaluated by blood counts and other analyses over the course of 1-2 months. Surface marker expression was assessed on T cells by flow cytometry and clonality by polymerase chain reaction. Intracellular cytokine evaluation, bone marrow and skin biopsies were performed during different parts

SUBMITTER: Khoury P 

PROVIDER: S-EPMC4349267 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature