Biliary multifocal chromosomal polysomy and cholangiocarcinoma in primary sclerosing cholangitis.

ABSTRACT:

Objectives

Polysomy detected by fluorescence in situ hybridization (FISH) is associated with cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC). However, a subset of PSC patients with polysomy do not manifest CCA even after long-term follow-up. It is unknown if patients with chromosomal gains detected by FISH in multiple areas of the biliary tree (i.e., multifocal polysomy, MFP) are more likely to be diagnosed with CCA than patients with unifocal polysomy (UFP). Therefore, our aim is to determine whether patients with MFP are more likely to manifest CCA compared with patients with other chromosomal abnormalities including UFP and other FISH subtypes.

Methods

We performed a retrospective review of PSC patients without a mass lesion who underwent FI

SUBMITTER: Eaton JE 

PROVIDER: S-EPMC4349337 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature