Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.

ABSTRACT:

Importance

There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease program was established to promote discovery of potential therapies.

Objective

To determine whether creatine monohydrate was more effective than placebo in slowing long-term clinical decline in participants with Parkinson disease.

Design, setting, and patients

The Long-term Study 1, a multicenter, double-blind, parallel-group, placebo-controlled, 1:1 randomized efficacy trial. Participants were recruited from 45 investigative sites in the United States and Canada and included 1741 men and women with early

SUBMITTER: Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators 

PROVIDER: S-EPMC4349346 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature