Preconception and prenatal environmental factors associated with communication impairments in 9 year old children using an exposome-wide approach.

ABSTRACT: Although speech and language deficits are common in children and strongly associated with poor educational and social outcomes, little attention has been paid to the antecedents. In this study we used the information from the Avon Longitudinal Study of Parents and Children to examine preconception and prenatal environmental risk factors that were related to communication difficulties in children using the Children's Communication Checklist (CCC). We used an exposome-wide approach to identify environmental factors univariably associated with the CCC. Taking account of the False Discovery rate, we used a P value of 0.000157 to identify 621 of 3855 items tested. These were then subjected to a series of stepwise linear regression analyses, firstly within 10 domains: personal characteristics, h

SUBMITTER: Steer CD 

PROVIDER: S-EPMC4349447 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature