Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue.

ABSTRACT:

Background

In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction of nanoparticles with body tissues, in particular within the cardiovascular system. Attention has recently focused on the link between environmental pollution and cardiovascular diseases. Nanoparticles <50 nm in size are known to pass the alveolar-pulmonary barrier, enter into bloodstream and induce inflammation, but the direct pathogenic mechanisms still need to be evaluated. We thus focused our attention on titanium dioxide (TiO₂) nanoparticles, the most diffuse nanomaterial in polluted environments and one generally considered inert for the human body.

Methods

We conducted functional studies on isolated adult rat cardiomyocytes exposed acutely in vitro

SUBMITTER: Savi M 

PROVIDER: S-EPMC4349471 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature