Differential reward network functional connectivity in cannabis dependent and non-dependent users.

ABSTRACT:

Background

Emergent studies show that similar to other substances of abuse, cue-reactivity to cannabis is also associated with neural response in the brain's reward pathway (Filbey et al., 2009). However, the inter-relatedness of brain regions during cue-reactivity in cannabis users remains unknown.

Methods

In this study, we conducted a series of investigations to determine functional connectivity during cue-reactivity in 71 cannabis users. First, we used psychophysiological interaction (PPI) analysis to examine coherent neural response to cannabis cues. Second, we evaluated whether these patterns of network functional connectivity differentiated dependent and non-dependent users. Finally, as an exploratory analysis, we determined the directionality of these connections via

SUBMITTER: Filbey FM 

PROVIDER: S-EPMC4349558 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature