Distinct behavioural and network correlates of two interneuron types in prefrontal cortex.

ABSTRACT: Neurons in the prefrontal cortex exhibit diverse behavioural correlates, an observation that has been attributed to cell-type diversity. To link identified neuron types with network and behavioural functions, we recorded from the two largest genetically defined inhibitory interneuron classes, the perisomatically targeting parvalbumin (PV) and the dendritically targeting somatostatin (SOM) neurons in anterior cingulate cortex of mice performing a reward foraging task. Here we show that PV and a subtype of SOM neurons form functionally homogeneous populations showing a double dissociation between both their inhibitory effects and behavioural correlates. Out of several events pertaining to behaviour, a subtype of SOM neurons selectively responded at reward approach, whereas PV neurons respond

SUBMITTER: Kvitsiani D 

PROVIDER: S-EPMC4349584 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature