A novel Schistosoma japonicum endonuclease homologous to DNase II.

ABSTRACT:

Background

Recent advances in studies of the Schistosoma japonicum genome have opened new avenues for the elucidation of parasite biology and the identification of novel targets for vaccines, drug development and early diagnostic tools.

Results

In this study, we surveyed the S. japonicum genome database for genes encoding nucleases. A total of 130 nucleases of 3 classes were found. Transcriptional analysis of these genes using a genomic DNA microarray revealed that the majority of the nucleases were differentially expressed in parasites of different developmental stages or different genders, whereas no obvious transcriptional variation was detected in parasites from different hosts. Further analysis of the putative DNases of S. japonicum revealed a novel DNase II homologue (

SUBMITTER: Hou N 

PROVIDER: S-EPMC4349608 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature