MiR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small non-coding RNAs that recognize sites of complementarity of target messenger RNAs, resulting in transcriptional regulation and translational repression of target genes. In Huntington's disease (HD), a neurodegenerative disease caused by a trinucleotide repeat expansion, miRNA dyregulation has been reported, which may impact gene expression and modify the progression and severity of HD.

Methods

We performed next-generation miRNA sequence analysis in prefrontal cortex (Brodmann Area 9) from 26 HD, 2 HD gene positive, and 36 control brains. Neuropathological information was available for all HD brains, including age at disease onset, CAG-repeat size, Vonsattel grade, and Hadzi-Vonsattel striatal and cortical scores, a continuous measure of

SUBMITTER: Hoss AG 

PROVIDER: S-EPMC4349621 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature