Co-prescription trends in a large cohort of subjects predict substantial drug-drug interactions.

ABSTRACT: Pharmaceutical prescribing and drug-drug interaction data underlie recommendations on drug combinations that should be avoided or closely monitored by prescribers. Because the number of patients taking multiple medications is increasing, a comprehensive view of prescribing patterns in patients is important to better assess real world pharmaceutical response and evaluate the potential for multi-drug interactions. We obtained self-reported prescription data from NHANES surveys between 1999 and 2010, and confirm the previously reported finding of increasing drug use in the elderly. We studied co-prescription drug trends by focusing on the 2009-2010 survey, which contains prescription data on 690 drugs used by 10,537 subjects. We found that medication profiles were unique for individuals aged

SUBMITTER: Sutherland JJ 

PROVIDER: S-EPMC4349653 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature