Discovery of putative small non-coding RNAs from the obligate intracellular bacterium Wolbachia pipientis.

ABSTRACT: Wolbachia pipientis is an endosymbiotic bacterium that induces a wide range of effects in its insect hosts, including manipulation of reproduction and protection against pathogens. Little is known of the molecular mechanisms underlying the insect-Wolbachia interaction, though it is likely to be mediated via the secretion of proteins or other factors. There is an increasing amount of evidence that bacteria regulate many cellular processes, including secretion of virulence factors, using small non-coding RNAs (sRNAs), but sRNAs have not previously been described from Wolbachia. We have used two independent approaches, one based on comparative genomics and the other using RNA-Seq data generated for gene expression studies, to identify candidate sRNAs in Wolbachia. We experimentally characteri

SUBMITTER: Woolfit M 

PROVIDER: S-EPMC4349823 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature