Handling class imbalance problem in miRNA dataset associated with cancer.

ABSTRACT: MiRNAs are small (~22nt long) non-coding RNA sequences; binds to the complementarity target sites in 3' Untranslated Region (UTR) of mRNA sequences but not restricted to other mRNA regions viz., 5' UTR and Coding sequences (CDS). Complementarity binding of miRNA to mRNA target sites either results in complete degradation of the mRNA itself or it may regulate the mRNA as an oncogene or as a tumor suppressor gene. However, the exact mechanism involved in identifying a miRNA to be associated with cancer is still unclear. Further, with the outburst in the number of miRNAs sequences recorded every year in miRBase, the gap is still widening mainly due to the laborious and economically unfavorable experimental procedures associated with the functional annotation. Motivated by the fact, we constru

SUBMITTER: Kothandan R 

PROVIDER: S-EPMC4349932 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature