Genome-wide identification of antimicrobial peptides in the liver fluke, Clonorchis sinensis.

ABSTRACT: The increase in prevalence of antimicrobial resistance makes the search for new antibiotic agents imperative. Antimicrobial peptides (AMPs) from natural resources have been recognized as suitable tools to combat antibiotic-resistant bacteria. The liver fluke Clonorchis sinensis living in germ-filled environments could be a good source of antimicrobials. Here, we report the use of a rational protocol that combines AMP predictions based on their physicochemical properties and their in vivo stability to discover AMP candidates from the entire genome of C. sinensis. To screen AMP candidates, in silico analyses based on the physicochemical properties of known AMPs, such as length, charge, isoelectric point, and in vitro and in vivo aggregation values were performed. To enhance their in vivo sta

SUBMITTER: Yoo WG 

PROVIDER: S-EPMC4349934 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature