Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.

ABSTRACT:

Unlabelled

Viral cellular immune surveillance is a dynamic and fluid system that is driven by finely regulated cellular processes including cytokines and other factors locally in the microenvironment and systemically throughout the body. It is questionable as to what extent the central nervous system (CNS) is an immune-privileged organ protected by the blood-brain barrier (BBB). Recent evidence suggests converging pathways through which viral infection, and its associated immune surveillance processes, may alter the integrity of the blood-brain barrier, and lead to inflammation, swelling of the brain parenchyma and associated neurological syndromes. Here, we expand upon the recent "gateway theory", by which viral infection and other immune activation states may disrupt the speciali

SUBMITTER: Barkhordarian A 

PROVIDER: S-EPMC4349940 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature