In vivo assessment of protease dynamics in cutaneous wound healing by degradomics analysis of porcine wound exudates.

ABSTRACT: Proteases control complex tissue responses by modulating inflammation, cell proliferation and migration, and matrix remodeling. All these processes are orchestrated in cutaneous wound healing to restore the skin's barrier function upon injury. Altered protease activity has been implicated in the pathogenesis of healing impairments, and proteases are important targets in diagnosis and therapy of this pathology. Global assessment of proteolysis at critical turning points after injury will define crucial events in acute healing that might be disturbed in healing disorders. As optimal biospecimens, wound exudates contain an ideal proteome to detect extracellular proteolytic events, are noninvasively accessible, and can be collected at multiple time points along the healing process from the sam

SUBMITTER: Sabino F 

PROVIDER: S-EPMC4350031 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature