Airway pressure release ventilation reduces conducting airway micro-strain in lung injury.

ABSTRACT:

Background

Improper mechanical ventilation can exacerbate acute lung damage, causing a secondary ventilator-induced lung injury (VILI). We hypothesized that VILI can be reduced by modifying specific components of the ventilation waveform (mechanical breath), and we studied the impact of airway pressure release ventilation (APRV) and controlled mandatory ventilation (CMV) on the lung micro-anatomy (alveoli and conducting airways). The distribution of gas during inspiration and expiration and the strain generated during mechanical ventilation in the micro-anatomy (micro-strain) were calculated.

Study design

Rats were anesthetized, surgically prepared, and randomized into 1 uninjured control group (n = 2) and 4 groups with lung injury: APRV 75% (n = 2), time at expiration (TLow

SUBMITTER: Kollisch-Singule M 

PROVIDER: S-EPMC4350231 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature