MicroRNA expression patterns in the malignant progression of gliomas and a 5-microRNA signature for prognosis.

ABSTRACT: MicroRNAs (miRNAs) are directly involved in the progression in various cancers. To date, no systematic researches have been performed on the expression pattern of miRNA during progression from low grade gliomas to anaplastic gliomas or secondary glioblastomas and those prognostic miRNAs in anaplastic gliomas and secondary glioblastomas. In the present study, high-throughput microarrays were used to measure miRNA expression levels in 116 samples in the different progression stages of glioma. We found that miRNA expression pattern totally altered when low grade gliomas progressed to anaplastic gliomas or secondary glioblastomas. However, anaplastic gliomas and secondary glioblastomas have similar expression pattern in miRNA level. Furthermore, we developed a five-miRNA signature (two protect

SUBMITTER: Yan W 

PROVIDER: S-EPMC4350338 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature