Correlation of in vivo and ex vivo (1)H-MRI with histology in two severities of mouse spinal cord injury.

ABSTRACT: Spinal cord injury (SCI) is a debilitating neuropathology with no effective treatment. Magnetic resonance imaging (MRI) technology is the only method used to assess the impact of an injury on the structure and function of the human spinal cord. Moreover, in pre-clinical SCI research, MRI is a non-invasive method with great translational potential since it provides relevant longitudinal assessment of anatomical and structural alterations induced by an injury. It is only recently that MRI techniques have been effectively used for the follow-up of SCI in rodents. However, the vast majority of these studies have been carried out on rats and when conducted in mice, the contusion injury model was predominantly chosen. Due to the remarkable potential of transgenic mice for studying the pathophysi

SUBMITTER: Noristani HN 

PROVIDER: S-EPMC4350395 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature