Genetic, psychosocial and clinical factors associated with hippocampal volume in the general population.

ABSTRACT: The hippocampus--crucial for memory formation, recall and mood regulation--is involved in the pathophysiology of dementia and depressive disorders. Recent genome-wide association studies (GWAS) have identified five genetic loci associated with hippocampal volume (HV). Previous studies have described psychosocial and clinical factors (for example, smoking, type 2 diabetes and hypertension) to have an impact on HV. However, the interplay between genetic, psychosocial and clinical factors on the HV remains unclear. Still, it is likely that genetic variants and clinical or psychosocial factors jointly act in modifying HV; it might be possible they even interact. Knowledge of these factors might help to quantify ones individual risk of or rather resilience against HV loss. We investigated subje

SUBMITTER: Janowitz D 

PROVIDER: S-EPMC4350511 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature