Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate.

ABSTRACT: Acamprosate supports abstinence in some alcohol-dependent subjects, yet predictors of response are unknown. To identify response biomarkers, we investigated associations of abstinence length with polymorphisms in candidate genes in glycine and glutamate neurotransmission pathways and genes previously implicated in acamprosate response. Association analyses were conducted in the discovery sample of 225 alcohol-dependent subjects treated with acamprosate for 3 months in community-based treatment programs in the United States. Data from 110 alcohol-dependent males treated with acamprosate in the study PREDICT were used for replication of the top association findings. Statistical models were adjusted for relevant covariates, including recruitment site and baseline clinical variables associated

SUBMITTER: Karpyak VM 

PROVIDER: S-EPMC4350512 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature