Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis.

ABSTRACT:

Background

Ipilimumab is a fully human monoclonal antibody directed against cytotoxic T-lymphocyte antigen-4 , a key negative regulator of T-cell activation approved by the Food and Drug Administration as of March 2011 for the treatment of metastatic melanoma. As a result of the up-regulation of the immune system, several immune-mediated adverse effects have been reported including colitis, dermatitis, hepatitis and rarely hypophysitis. The most frequent immune-mediated adverse effects described in literature include gastrointestinal toxicity such as diarrhea, colitis and case of colitis and ileitis.

Case presentation

In this paper we report an interesting case of immune-mediate ileitis without colitis in a 54 years old woman with metastatic melanoma treated with ipilimumab.

SUBMITTER: Venditti O 

PROVIDER: S-EPMC4350587 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature