DNA methylation age of blood predicts all-cause mortality in later life.

ABSTRACT:

Background

DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biological age.

Results

Here we test whether differences between people's chronological ages and estimated ages, DNA methylation age, predict all-cause mortality in later life. The difference between DNA methylation age and chronological age (Δage) was calculated in four longitudinal cohorts of older people. Meta-analysis of proportional hazards models from the four cohorts was used to determine the association between Δage and mortality. A 5-year higher Δage is associated with a 21% higher mortality risk, adjusting for age and sex. After further adjustments for c

SUBMITTER: Marioni RE 

PROVIDER: S-EPMC4350614 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature