Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II.

ABSTRACT: Post-translational modifications of the heptad repeat sequences in the C-terminal domain (CTD) of RNA polymerase II (Pol II) are well recognized for their roles in coordinating transcription with other nuclear processes that impinge upon transcription by the Pol II machinery; and this is primarily achieved through CTD interactions with the various nuclear factors. The identification of novel modifications on new regulatory sites of the CTD suggests that, instead of an independent action for all modifications on CTD, a combinatorial effect is in operation. In this review we focus on two well-characterized modifications of the CTD, namely serine phosphorylation and prolyl isomerization, and discuss the complex interplay between the enzymes modifying their respective regulatory sites. We summ

SUBMITTER: Yogesha SD 

PROVIDER: S-EPMC4350670 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature