Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls.

ABSTRACT:

Background

Gene expression in archived newborn blood spots remaining from newborn screening may reflect pathophysiological disturbances useful in understanding the etiology of cerebral palsy (CP).

Methods

We quantified the expression of gene sets representing four physiological pathways hypothesized to contribute to CP in archived unfrozen residual newborn blood spot specimens from 53 children with CP and 53 age-, gender-, and gestational age-matched controls. We selected four empirical and three canonical gene sets representing the inflammatory, hypoxic, coagulative, and thyroidal pathways and examined mRNA expression using an 8 × 60,000 oligonucleotide microarray. The log2 fold change of gene expression between matched cases and controls was analyzed using the generally ap

SUBMITTER: Ho NT 

PROVIDER: S-EPMC4350763 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature