Endothelial-mesenchymal transition of brain endothelial cells: possible role during metastatic extravasation.

ABSTRACT: Cancer progression towards metastasis follows a defined sequence of events described as the metastatic cascade. For extravasation and transendothelial migration metastatic cells interact first with endothelial cells. Yet the role of endothelial cells during the process of metastasis formation and extravasation is still unclear, and the interaction between metastatic and endothelial cells during transendothelial migration is poorly understood. Since tumor cells are well known to express TGF-β, and the compact endothelial layer undergoes a series of changes during metastatic extravasation (cell contact disruption, cytoskeletal reorganization, enhanced contractility), we hypothesized that an EndMT may be necessary for metastatic extravasation. We demonstrate that primary cultured rat brain en

SUBMITTER: Krizbai IA 

PROVIDER: S-EPMC4350839 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature