Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial.

ABSTRACT:

Background

Critical shortages of organs for transplantation jeopardize many lives. Observational data suggest that better fluid management for deceased organ donors could increase organ recovery. We conducted the first large multicenter randomized trial in brain-dead donors to determine whether protocolized fluid therapy increases the number of organs transplanted.

Methods

We randomly assigned donors to either protocolized or usual care in eight organ procurement organizations. A "protocol-guided fluid therapy" algorithm targeting the cardiac index, mean arterial pressure and pulse pressure variation was used. Our primary outcome was the number of organs transplanted per donor, and our primary analysis was intention to treat. Secondary analyses included: (1) modified intenti

SUBMITTER: Al-Khafaji A 

PROVIDER: S-EPMC4351113 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature