An extended Swedish national adoption study of alcohol use disorder.

ABSTRACT:

Importance

Alcohol use disorder (AUD) runs strongly in families. It is unclear to what extent the cross-generational transmission of AUD results from genetic vs environmental factors.

Objective

To determine to what extent genetic and environmental factors contribute to the risk for AUD.

Design, setting, and participants

Follow-up in 8 public data registers of adoptees, their biological and adoptive relatives, and offspring and parents from stepfamilies and not-lived-with families in Sweden. In this cohort study, subtypes of AUD were assessed by latent class analysis. A total of 18,115 adoptees (born 1950-1993) and 171,989 and 107,696 offspring of not-lived-with parents and stepparents, respectively (born 1960-1993).

Main outcomes and measures

Alcohol use disord

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC4351126 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature