Subgingival microbial communities in Leukocyte Adhesion Deficiency and their relationship with local immunopathology.

ABSTRACT: Leukocyte Adhesion Deficiency I (LAD-I) is a primary immunodeficiency caused by single gene mutations in the CD18 subunit of β2 integrins which result in defective transmigration of neutrophils into the tissues. Affected patients suffer from recurrent life threatening infections and severe oral disease (periodontitis). Microbial communities in the local environment (subgingival plaque) are thought to be the triggers for inflammatory periodontitis, yet little is known regarding the microbial communities associated with LAD-I periodontitis. Here we present the first comprehensive characterization of the subgingival communities in LAD-I, using a 16S rRNA gene-based microarray, and investigate the relationship of this tooth adherent microbiome to the local immunopathology of periodontitis. We

SUBMITTER: Moutsopoulos NM 

PROVIDER: S-EPMC4351202 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature