An animal model of a newly emerging human ehrlichiosis.

ABSTRACT:

Background

Human ehrlichioses are emerging life-threatening diseases transmitted by ticks. Animal models have been developed to study disease development; however, there is no valid small animal model that uses a human ehrlichial pathogen. The objective of this study was to develop a mouse model for ehrlichiosis with the newly discovered human pathogen, Ehrlichia muris-like agent (EMLA).

Methods

Three strains of mice were inoculated with different doses of EMLA by the intravenous, intraperitoneal, or intradermal route and evaluated for clinical and pathologic changes during the course of infection.

Results

EMLA infected C57Bl/6, BALB/c, and C3H/HeN mice and induced lethal or persistent infection in a route- and dose-dependent manner. The clinical chemistry and hematol

SUBMITTER: Saito TB 

PROVIDER: S-EPMC4351372 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature