Additive effects of gastric volumes and macronutrient composition on the sensation of postprandial fullness in humans.

ABSTRACT:

Background/objectives

Intake of food or fluid distends the stomach and triggers mechanoreceptors and vagal afferents. Wall stretch and tension produces a feeling of fullness. Duodenal infusion studies assessing gastric sensitivity by barostat have shown that the products of fat digestion have a greater effect on the sensation of fullness and also dyspeptic symptoms than carbohydrates. We tested here the hypothesis that fat and carbohydrate have different effects on gastric sensation under physiological conditions using non-invasive magnetic resonance imaging (MRI) to measure gastric volumes.

Subjects/methods

Thirteen healthy subjects received a rice pudding test meal with added fat or added carbohydrate on two separate occasions and underwent serial postprandial MRI scans fo

SUBMITTER: Marciani L 

PROVIDER: S-EPMC4351404 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature