Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance.

ABSTRACT:

Aims/hypothesis

Nicotinamide-N-methyltransferase (NNMT) was recently shown to be upregulated in mouse models of insulin resistance and obesity. So far, it is unknown whether NNMT is regulated in human disease. We have explored the hypothesis that white adipose tissue (WAT) NNMT expression and plasma 1-methylnicotinamide (MNA) concentration are increased in human insulin resistance and type 2 diabetes.

Methods

NNMT expression and plasma MNA were analysed in three groups of individuals: (1) 199 patients undergoing abdominal surgery; (2) 60 individuals on a 12-week exercise programme and (3) 55 patients on a two-step bariatric surgery programme.

Results

Patients with manifest type 2 diabetes have a significantly (approximately twofold) higher NNMT expression both in omen

SUBMITTER: Kannt A 

PROVIDER: S-EPMC4351435 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature