Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease.

ABSTRACT:

Objectives

We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease.

Methods

We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebral hemorrhage and its subtypes (deep, lobar) (1,545 cases, 1,485 controls); ischemic stroke and its subtypes (cardioembolic, large vessel disease, lacunar) (12,389 cases, 62,004 controls); and white matter hyperintensities (2,733 individuals with ischemic stroke and 9,361 from population-based cohorts with brain MRI data). We calculated a statistical significance threshold that acc

SUBMITTER: Rannikmae K 

PROVIDER: S-EPMC4351667 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature