Obsessive-compulsive disorder is associated with broad impairments in executive function: A meta-analysis.

ABSTRACT: Obsessive-compulsive disorder (OCD) is a serious and often chronically disabling condition. The current dominant model of OCD focuses on abnormalities in prefrontal-striatal circuits that support executive function (EF). While there is growing evidence for EF impairments associated with OCD, results have been inconsistent, making the nature and magnitude of these impairments controversial. The current meta-analysis uses random-effects models to synthesize 110 previous studies that compared participants with OCD to healthy control participants on at least one neuropsychological measure of EF. The results indicate that individuals with OCD are impaired on tasks measuring most aspects of EF, consistent with broad impairment in EF. EF deficits were not explained by general motor slowness or de

SUBMITTER: Snyder HR 

PROVIDER: S-EPMC4351670 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature